SAGE-217

SAGE-217

CAT N°: 31755
Price:

From 49.00 41.65

SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing ?4?2?2 subunit-containing GABAA receptors and CHO cells expressing ?4?3? subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[(3?,5?)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile
  • Correlated keywords
    • SAGE217 SGE797 S812217 Zuranolone GABA-A
  • Product Overview:
    SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing ?4?2?2 subunit-containing GABAA receptors and CHO cells expressing ?4?3? subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.

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