Ganglioside G<sub>M3</sub> (bovine buttermilk) (ammonium salt)

Ganglioside GM3 (bovine buttermilk) (ammonium salt)

CAT N°: 31711
Price:

322.00 273.70

Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.{25490,25485} It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 ?M via inhibition of VEGFR2 and Akt phosphorylation.{25490,25485} Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance in adipocytes.{25481} This product contains ganglioside GM3 molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1503]

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