Dehydroandro<wbr/>grapholide

Dehydroandrographolide

CAT N°: 31625
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From 48.00 40.80

Dehydroandrographolide is a diterpene that has been found in A. paniculata and has diverse biological activities.{64637,64638,64636} It inhibits DNA replication of hepatitis B virus (HBV) in HepG2 2.2.15 cells (IC50 = 22.6 µM). Dehydroandrographolide (50 µM) inhibits anoctamin 1 (ANO1), also known as TMEM16A, chloride currents in Fisher rat thyroid cells expressing human ANO1 and SW620 colorectal cancer cells.{64638} It inhibits the proliferation of SW620 colorectal cancer cells in a concentration-dependent manner. Dehydroandrographolide reduces the release of histamine, tryptase beta, ?-hexosaminidase, TNF-?, and chemokine (C-C motif) ligand 2 (CCL2), as well as inhibits cellular degranulation induced by the neuropeptide substance P (SP), in LAD 2 and mouse primary mast cells in a concentration-dependent manner.{64636} It upregulates phosphorylation of Src homology region 2 domain-containing phosphatase 1 (SHP-1) and SHP-2 in LAD 2 cells with CD300f knocked down using siRNA when used at a concentration of 50 µM. Dehydroandrographolide inhibits SP-induced mast cell degranulation and reduces mouse serum levels of histamine, tryptase beta 2, TNF-?, CCL2, and chemokine (C-X-C) ligand 2 (CXCL2) in vivo when administered at a dose of 1 or 2 mg/kg.

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