G6PDi-1

G6PDi-1

CAT N°: 31484
Price:

From 92.00 78.20

G6PDi-1 is a reversible and noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PDH; IC50 = 0.07 µM), the enzyme that converts G6P to 6-phosphogluconolactone using NADP+ as a cofactor in the first step of the pentose phosphate pathway.{55375} G6PDi-1 (10 and 50 µM) reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells. It decreases colony formation of HCT116 cells when used at concentrations of 20 and 30 µM, an effect that can be rescued by the antioxidant N-acetyl cysteine. G6PDi-1 decreases the production of cytokines induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item No. 10004974) in T cells and prevents PMA-induced oxidative burst in neutrophils.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-((5-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile
  • Correlated keywords
    • G6DPi1 G6P DH 6phosphogluconolactone NADP + HCT 116 12myristate 13acetate Tcell
  • Product Overview:
    G6PDi-1 is a reversible and noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PDH; IC50 = 0.07 µM), the enzyme that converts G6P to 6-phosphogluconolactone using NADP+ as a cofactor in the first step of the pentose phosphate pathway.{55375} G6PDi-1 (10 and 50 µM) reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells. It decreases colony formation of HCT116 cells when used at concentrations of 20 and 30 µM, an effect that can be rescued by the antioxidant N-acetyl cysteine. G6PDi-1 decreases the production of cytokines induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item No. 10004974) in T cells and prevents PMA-induced oxidative burst in neutrophils.

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