Xaliproden (hydro<wbr/>chloride)

Xaliproden (hydrochloride)

CAT N°: 31468
Price:

94.00 79.90

Xaliproden is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 4.3 nM in a radioligand binding assay).{59032} It is selective for 5-HT1A over 5-HT2 and ?1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ?10 µM for all) but also binds sigma (?) receptors (IC50 = 73 nM). Xaliproden (250 nM) increases NGF-induced neurite outgrowth and ?-actinin levels in PC12 cells.{59033} It decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by four-vessel occlusion (4-VO) and sciatic nerve crush injury, respectively, when administered at a dose of 10 mg/kg per day.{59034} Xaliproden (10 mg/kg per day) inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein.{59035}

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