5-Methoxycanthinone

5-Methoxycanthinone

CAT N°: 31342
Price:

From 313.00 266.05

5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.{60001} It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 µg/ml, respectively).{60005} However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.{60006}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
  • Correlated keywords
    • Methoxy-canthin canthinone NSC88929 Lactuca anti-cancer A-549 HCT8 Plasmodium F-32 multi-drug
  • Product Overview:
    5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.{60001} It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 µg/ml, respectively).{60005} However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.{60006}

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