Indole-3-carbox<wbr/>aldehyde

Indole-3-carboxaldehyde

CAT N°: 31328
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From 66.00 56.10

Indole-3-carboxyaldehyde is an active metabolite of tryptophan and a synthetic intermediate.{53935,53936,53937} It is produced by lactobacilli in the gut microbiota via the indole pyruvate pathway, which is catalyzed by aromatic amino acid aminotransferase (ArAT).{53935} Indole-3-carboxyaldehyde (18 mg/kg) increases colonic production of IL-22 and restores colonization resistance to C. albicans infection in a wild-type, but not aryl hydrocarbon receptor knockout (Ahr-/-), mouse model of mucosal candidiasis. It also reduces intestinal mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250). Indole-3-carboxaldehyde has been used as a synthetic intermediate in the synthesis of Schiff bases and ergot alkaloids.{53936,53937}

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