Adiphenine (hydrochloride)

Adiphenine (hydrochloride)

CAT N°: 31124
Price:

From 54.00 45.90

Adiphenine is an anticholinergic agent.{52813,52814,52815,52816} It is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50s = 1.8, 3.7, and 6.3 µM for the ?3?4, ?4?2, and ?4?4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM).{52813,52814} Adiphenine inhibits contractions induced by acetylcholine (ACh) in isolated guinea pig ileum in a concentration-dependent manner.{52814} It prevents tonic hindlimb extension in a mouse model of seizures induced by maximal electroshock (MES) with an ED50 value of 62 mg/kg but is neurotoxic at higher doses.{52815} Adiphenine protects against organophosphate-induced lethality in mice with a 50% protective dose (PD50) value of 3.3 mg/kg.{52816} It has also been used as a local anesthetic.{52813,52815}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • ?-phenyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride
  • Correlated keywords
    • 64-95-9 NSC129224 IC 50 ED PD
  • Product Overview:
    Adiphenine is an anticholinergic agent.{52813,52814,52815,52816} It is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50s = 1.8, 3.7, and 6.3 µM for the ?3?4, ?4?2, and ?4?4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM).{52813,52814} Adiphenine inhibits contractions induced by acetylcholine (ACh) in isolated guinea pig ileum in a concentration-dependent manner.{52814} It prevents tonic hindlimb extension in a mouse model of seizures induced by maximal electroshock (MES) with an ED50 value of 62 mg/kg but is neurotoxic at higher doses.{52815} Adiphenine protects against organophosphate-induced lethality in mice with a 50% protective dose (PD50) value of 3.3 mg/kg.{52816} It has also been used as a local anesthetic.{52813,52815}

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