Eurycomanone

Eurycomanone

CAT N°: 30896
Price:

From 68.00 57.80

Eurycomanone is a quassinoid originally isolated from E. longifolia that has diverse biological activities.{59000} It is active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml, respectively).{59002} Eurycomanone induces lipolysis in 3T3-L1 adipocytes with an EC50 value of 14.6 µM, an effect that can be blocked by the protein kinase A (PKA) inhibitor H-89 (Item No. 10010556).{59001} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells when used at a concentration of 5 µg/ml.{59003} It reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations when used at concentrations of 1 and 10 µM.{59004} Eurycomanone (1 mg/kg, i.p.) decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation.{59005}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1?,11?,12?,15?)-11,20-epoxy-1,11,12,14,15-pentahydroxy-picrasa-3,13(21)-diene-2,16-dione
  • Correlated keywords
    • NSC339187 Eurycoma W-2 D-6 Plasmodium 3T3L1 H89 Hep-G2 G-2
  • Product Overview:
    Eurycomanone is a quassinoid originally isolated from E. longifolia that has diverse biological activities.{59000} It is active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml, respectively).{59002} Eurycomanone induces lipolysis in 3T3-L1 adipocytes with an EC50 value of 14.6 µM, an effect that can be blocked by the protein kinase A (PKA) inhibitor H-89 (Item No. 10010556).{59001} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells when used at a concentration of 5 µg/ml.{59003} It reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations when used at concentrations of 1 and 10 µM.{59004} Eurycomanone (1 mg/kg, i.p.) decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation.{59005}

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