Cinanserin (hydro<wbr/>chloride)

Cinanserin (hydrochloride)

CAT N°: 30729
Price:

From 140.00 119.00

Cinanserin is a serotonin (5-HT) receptor antagonist.{61112,61113} It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum.{61112} Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward.{61113} It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLpro; IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM).{61114} It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).{32157}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride
  • Correlated keywords
    • 1166-34-3 5HT corona virus SARSCoV MAPTC BHKRep 1 BHK Rep1
  • Product Overview:
    Cinanserin is a serotonin (5-HT) receptor antagonist.{61112,61113} It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum.{61112} Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward.{61113} It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLpro; IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM).{61114} It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).{32157}

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