Aurintri<wbr/>carboxylic Acid (ammonium salt)

Aurintricarboxylic Acid (ammonium salt)

CAT N°: 30636
Price:

From 74.00 62.90

Aurintricarboxylic acid (ATA) is an inhibitor of protein synthesis that has diverse biological activities.{54334,54335,54336,54337,54338,54339,54340,54341} It inhibits the activity of a variety of enzymes, including the nucleases DNase I, RNase A, and S1, as well as the serine proteases trypsin and chymotrypsin in a concentration-dependent manner.{54335,54336} ATA inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV; EC50 = 200 µg/ml) and human enterovirus 71 in Vero cells (EV71; EC50 = 2.9 µM), as well as reduces HIV-1- or HIV-2-induced cytopathogenicity in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively).{54337,54338,54339} It inhibits apoptosis induced by sanguinarine (Item No. 16951) in K562 leukemia cells when used at a concentration of 100 µM.{54340} ATA (20 mg/kg, i.p.) decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).{54341}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,3?-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxy-benzoic acid, triammonium salt
  • Correlated keywords
    • 857155-55-6 25329-64-0 144097-08-5 929976-57-8 956084-23-4 Aurin tricarboxylic aluminon S 1 EV 71 HIV1 HIV2 MT4 CD 4+
  • Product Overview:
    Aurintricarboxylic acid (ATA) is an inhibitor of protein synthesis that has diverse biological activities.{54334,54335,54336,54337,54338,54339,54340,54341} It inhibits the activity of a variety of enzymes, including the nucleases DNase I, RNase A, and S1, as well as the serine proteases trypsin and chymotrypsin in a concentration-dependent manner.{54335,54336} ATA inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV; EC50 = 200 µg/ml) and human enterovirus 71 in Vero cells (EV71; EC50 = 2.9 µM), as well as reduces HIV-1- or HIV-2-induced cytopathogenicity in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively).{54337,54338,54339} It inhibits apoptosis induced by sanguinarine (Item No. 16951) in K562 leukemia cells when used at a concentration of 100 µM.{54340} ATA (20 mg/kg, i.p.) decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).{54341}

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