SLM6031434 (hydrochloride)

SLM6031434 (hydrochloride)

CAT N°: 30434
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From 182.00 154.70

SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 ?M for the recombinant mouse enzyme).{38413} It is selective for SPHK2 over SPHK1 (Kis = >20 ?M). It decreases sphingosine-1-phosphate (S1P; Item No. 62570) and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.

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