€474.00 €402.90
Optineurin (OPTN) is an adapter protein with roles in autophagy, vesicular trafficking, and inflammatory responses to viral and bacterial pathogens.{47745} OPTN binds to ubiquitinated cargo via its ubiquitin-binding domain and targets them for autophagic degradation by recruiting LC3-expressing phagophore membranes via its LC3-interacting region. It is phosphorylated by TANK binding kinase 1 (TBK1), which increases the binding affinity of OPTN for polyubiquitinated mitochondria, promotes TBK1 activation and recruitment to the mitochondria, and permits the degradation of damaged mitochondria via PINK1/parkin-dependent mitophagy.{47746} OPTN regulates transferrin receptor trafficking and recycling by mediating the association between the membrane trafficking protein Rab8 and its activator TBC1D17.{47747} Mutation of the OPTN ubiquitin binding domain reduces LPS- and poly(I:C)-induced increases in IFN-? levels in bone marrow-derived macrophages (BMDMs).{47748} OPTN knockout increases mortality and reduces plasma levels of TNF-? and IL-6 in a mouse model of E. coli-induced peritonitis.{47749} Mutations in OPTN are associated with primary open angle glaucoma, amyotrophic lateral sclerosis (ALS), Paget’s disease, and Alzheimer’s disease.{47745,47750} Cayman’s Optineurin Monoclonal Antibody (Clone 8E12) can be used for immunocytochemistry applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | Peptide from C-terminal region of human optineurin protein |
| Clone | 8E+12 |
| Isotype | IgG1 |
| Application(s) | ICC |
| Formulation | 100 µg of protein G-purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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