Sclareol

Sclareol

CAT N°: 30287
Price:

From 54.00 45.90

Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 ?g/ml, respectively).{53621} Sclareol (5 and 10 ?g/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces ?-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 ?M), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 ?M.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?R,1R,2R,4aS,8aS)-?-ethenyldecahydro-2-hydroxy-?,2,5,5,8a-pentamethyl-1-naphthalenepropanol
  • Correlated keywords
    • 17904-64-2 886030-32-6 COX2 HCT-116 Salvia Actinomyces Porphyromonas Peptostreptococcus Lipopolysaccharide
  • Product Overview:
    Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 ?g/ml, respectively).{53621} Sclareol (5 and 10 ?g/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces ?-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 ?M), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 ?M.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.

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