Tenofovir diphosphate (sodium salt)

Tenofovir diphosphate (sodium salt)

CAT N°: 27057
Price:

1,274.00 1,082.90

Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 µM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 µM).{47282,47283} It is selective for these enzymes over DNA polymerase ? and ?, as well as mitochondrial DNA polymerase ? (Kis = 5.2, 81.7, and 59.5 µM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir (Item No. 13874) and tenofovir disoproxil (Item No. 16922) by nucleotide kinases.{24528} Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.{47284}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • diphosphoric acid, anhydride with [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid, disodium salt
  • Correlated keywords
    • HI HB V pro-drugs PBMC PMPA pp TFVDP 166403-66-3
  • Product Overview:
    Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 µM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 µM).{47282,47283} It is selective for these enzymes over DNA polymerase ? and ?, as well as mitochondrial DNA polymerase ? (Kis = 5.2, 81.7, and 59.5 µM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir (Item No. 13874) and tenofovir disoproxil (Item No. 16922) by nucleotide kinases.{24528} Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.{47284}

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