From €92.00 €78.20
Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities.{55083,55084,55085} It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 µM.{55083} Neotuberostemonine (50 µM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells.{55084} It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 µmol/kg.{55085} Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.{55083}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 143120-46-1 |
| Molecular formula | C22H33NO4 |
| Smiles | O=C(O1)[C@@H](C)[C@]2([H])[C@@]1([H])[C@H](CC)[C@]3([H])[C@]4([H])[C@@]2([H])C[C@]([C@@]5([H])OC([C@@H](C)C5)=O)([H])N4CCCC3 |
| Molecular weight | 375,5 |
| Custom code | 2932.20 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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