Alantolactone

Alantolactone

CAT N°: 29762
Price:

From 109.00 92.65

Alantolactone is a sesquiterpene lactone that has been found in Inula species and has diverse biological activities.{52342,52343,52344} It inhibits LPS-induced increases in nitric oxide, IL-6, and TNF-? production in RAW 246.7 cells by 76.09, 81.54, and 71.23%, respectively, when used at a concentration of 10 ?M.{52342} Alantolactone (40 ?M) decreases cell viability, glutathione (GSH) levels, and the mitochondrial membrane potential, induces apoptosis, and increases generation of reactive oxygen species (ROS) in HepG2 cells.{52343} It inhibits phosphorylation and nuclear translocation of STAT3 in MDA-MB-231 cells in a concentration-dependent manner.{52344} Alantolactone (2.5 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.

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