3-TYP

3-TYP

CAT N°: 29660
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From 102.00 86.70

3-TYP is a sirtuin 3 (SIRT3) inhibitor (IC50 = 38 ?M).{48840} It is selective for SIRT3 over SIRT1 and SIRT2 at 1 mM. 3-TYP (1 mM) increases acetylation of lysine residues in mitochondrial proteins in HeLa cells. It inhibits the growth of CCRF-CEM, COLO 205, OVCAR-4, OVCAR-8, and SKOV3 cells by greater than 50% when used at a concentration of 10 ?M.

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