KY 05009

KY 05009

CAT N°: 29552
Price:

From 55.00 46.75

KY 05009 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK; Ki = 100 nM).{47794} It inhibits TGF-?1-induced Wnt, NF-?B, ERK, and JNK signaling and prevents TGF-?1-induced epithelial-to-mesenchymal transition (EMT) in A549 lung cancer cells without inducing cytotoxicity when used at a concentration of 10 ?M. KY 05009 inhibits TNF-?1-induced A549 cell migration. It also induces apoptosis in RPMI-8226 multiple myeloma cells in a concentration-dependent manner.{47795}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
  • Correlated keywords
    • KY05009 TRAF TGF?1 NF?B A 549 cyto-toxicity RPMI8226
  • Product Overview:
    KY 05009 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK; Ki = 100 nM).{47794} It inhibits TGF-?1-induced Wnt, NF-?B, ERK, and JNK signaling and prevents TGF-?1-induced epithelial-to-mesenchymal transition (EMT) in A549 lung cancer cells without inducing cytotoxicity when used at a concentration of 10 ?M. KY 05009 inhibits TNF-?1-induced A549 cell migration. It also induces apoptosis in RPMI-8226 multiple myeloma cells in a concentration-dependent manner.{47795}

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