RN-9893 (hydro<wbr/>chloride)

RN-9893 (hydrochloride)

CAT N°: 29172
Price:

51.00 43.35

RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 ?M, respectively, for the human and rat receptors).{52086} It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 ?M, respectively). RN-9893 reduces rat TRPV4 activity induced by 4?-phorbol 12,13-didecanoate (4?-PDD; Item No. 20446) or hypotonicity (IC50s = 0.57 and 2.1 ?M, respectively, in cell free assays).

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