(–)-Triptonide

(–)-Triptonide

CAT N°: 29156
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From 92.00 78.20

(–)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties.{52152,52153} It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively).{52152} (–)-Triptonide inhibits the proliferation of PC3, DU145, and LNCaP cells (IC50s = 11.96, 10.26, 12.01 nM, respectively).{52153} It induces cell cycle arrest at the G2/M phase and increases apoptosis in PC3 cells in a concentration-dependent manner. (–)-Triptonide (10 mg/kg per day) reduces tumor growth in a PC3 mouse xenograft model.

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