SS-208

SS-208

CAT N°: 29128
Price:

From 122.00 103.70

SS-208 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 12 nM).{50457} It is selective for HDAC6 over HDAC1, -4, -5, -7, -8, -9, and -11 (IC50s = 1.39, 19.5, 6.91, 8.34, 1.23, 38.2, and 5.12 µM, respectively). SS-208 (0.1-25 µM) inhibits HDAC6 in, but does not induce cell death of, human PC3 prostate, 5637 and T24 bladder, and murine SM1 melanoma cells in vitro. It decreases protein levels of programmed death ligand 1 (PD-L1) in SM1 cells when used at a concentration of 5 µM. SS-208 (25 mg/kg, i.p.) reduces tumor growth and increases the number of intratumoral CD8+, CD4+, and natural killer (NK) T cells in an SM1 murine melanoma model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-3-isoxazolecarboxamide
  • Correlated keywords
    • SS208 HDAC 6 1 HDAC5 HDAC7 HDAC8 HDAC9 HDAC11 PC-3 T-24 SM CD 8+ CD 8 + 4+ 4
  • Product Overview:
    SS-208 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 12 nM).{50457} It is selective for HDAC6 over HDAC1, -4, -5, -7, -8, -9, and -11 (IC50s = 1.39, 19.5, 6.91, 8.34, 1.23, 38.2, and 5.12 µM, respectively). SS-208 (0.1-25 µM) inhibits HDAC6 in, but does not induce cell death of, human PC3 prostate, 5637 and T24 bladder, and murine SM1 melanoma cells in vitro. It decreases protein levels of programmed death ligand 1 (PD-L1) in SM1 cells when used at a concentration of 5 µM. SS-208 (25 mg/kg, i.p.) reduces tumor growth and increases the number of intratumoral CD8+, CD4+, and natural killer (NK) T cells in an SM1 murine melanoma model.

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