Efaroxan (hydro<wbr/>chloride)

Efaroxan (hydrochloride)

CAT N°: 29008
Price:

From 55.00 46.75

Efaroxan is an ?2-adrenergic receptor (?2-AR; EC50s = 1 receptor antagonist.{52072} It binds to ?2A-, ?2B-, and ?2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively). Efaroxan is an I3 agonist that binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion when used at a concentration of 100 ?M.{52073} It also binds to rat RIN-5AH insulinoma cell membranes (IC50 = 32 nM) and stimulates insulin secretion when used at a concentration of 100 ?M.{52074} Efaroxan (5 mg/kg) lowers basal blood glucose levels in mice.{52075} It also increases 3,4-dihydroxyphenylalanine (L-DOPA; Item No. 13248) synthesis in rat cortex and hippocampus by 77 and 57%, respectively, when administered at a dose of 10 mg/kg.{52076}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole, monohydrochloride
  • Correlated keywords
    • 89197-32-0 RX821037 ?2AR I-1 I-2 I-3 ?2BAR ?2CAR ?-2 RIN5AH RIN5-AH dihydroxy phenylalanine
  • Product Overview:
    Efaroxan is an ?2-adrenergic receptor (?2-AR; EC50s = 1 receptor antagonist.{52072} It binds to ?2A-, ?2B-, and ?2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively). Efaroxan is an I3 agonist that binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion when used at a concentration of 100 ?M.{52073} It also binds to rat RIN-5AH insulinoma cell membranes (IC50 = 32 nM) and stimulates insulin secretion when used at a concentration of 100 ?M.{52074} Efaroxan (5 mg/kg) lowers basal blood glucose levels in mice.{52075} It also increases 3,4-dihydroxyphenylalanine (L-DOPA; Item No. 13248) synthesis in rat cortex and hippocampus by 77 and 57%, respectively, when administered at a dose of 10 mg/kg.{52076}

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