Aceclofenac

Aceclofenac

CAT N°: 28620
Price:

From 46.00 39.10

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) and a derivative of diclofenac (Item Nos. 22983 | 70680).{48541} Aceclofenac inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) by 25 and 30%, respectively, in cell-free assays when used at concentrations of 10 and 100 µM, respectively. It selectively inhibits COX-2 in isolated whole blood (IC50s = 0.8 and >100 µM for COX-2 and COX-1, respectively) and inhibits the production of PGE2 in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM).{48541,48542} Aceclofenac reduces IL-1?-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, when used at a concentration of 30 ?M.{48541} Aceclofenac inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats.{48543} It also inhibits an increase in joint diameter in a rat model of arthritis induced by complete Freund’s adjuvant (CFA).{48544}

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