Gastric Inhibitory Peptide (human) (trifluoro<wbr/>acetate salt)

Gastric Inhibitory Peptide (human) (trifluoroacetate salt)

CAT N°: 25004
Price:

€451.00 €383.35

Gastric inhibitory peptide (GIP) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion in response to glucose.{41496} It belongs to the secretin/glucagon superfamily of peptides, which includes secretin (Item Nos. 24990 | 24561), glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).{36556} GIP is a GIP receptor agonist that binds to rat recombinant GIP receptors expressed in CHO-K1 cells (IC50 = 3.2 nM) and increases cAMP accumulation (EC50 = 377 pM).{42027} It stimulates insulin secretion from BRIN-BD11 rat pancreatic ?-cells when used at a concentration of 10 nM.{42028} GIP (1 pmol/min per 100 g) decreases blood glucose level and increases plasma insulin level in rats following glucose challenge.{42027} It also decreases plasma glucose level and increases insulin level in ob/ob mice following glucose challenge when administered at a dose of 25 nmol/kg.{42029}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-tyrosyl-L-alanyl-L-?-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-?-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-?-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-?-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-asparaginyl-L-?-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonyl-L-glutamine, trifluoroacetate salt
  • Correlated keywords
    • 91930-95-9 281200-78-0 100040-31-1 GLP1 GLP2 CHOK1 BRINBD-11 BRINBD11
  • Product Overview:
    Gastric inhibitory peptide (GIP) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion in response to glucose.{41496} It belongs to the secretin/glucagon superfamily of peptides, which includes secretin (Item Nos. 24990 | 24561), glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).{36556} GIP is a GIP receptor agonist that binds to rat recombinant GIP receptors expressed in CHO-K1 cells (IC50 = 3.2 nM) and increases cAMP accumulation (EC50 = 377 pM).{42027} It stimulates insulin secretion from BRIN-BD11 rat pancreatic ?-cells when used at a concentration of 10 nM.{42028} GIP (1 pmol/min per 100 g) decreases blood glucose level and increases plasma insulin level in rats following glucose challenge.{42027} It also decreases plasma glucose level and increases insulin level in ob/ob mice following glucose challenge when administered at a dose of 25 nmol/kg.{42029}

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