PSB-12379

PSB-12379

CAT N°: 28446
Price:

From 85.00 72.25

PSB-12379 is an inhibitor of ecto-5’-nucleotidase (CD73; Kis = 2.21 and 9.03 nM for the recombinant human and rat enzyme, respectively).{50087} It is selective for CD73 over human nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), -2, and -3, ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), -2, and -3 (Kis = >10,000 nM for all), as well as the purinergic P2Y1 and P2Y12 receptors at 10 µM. PSB-12379 inhibits CD73 in isolated human serum with a Ki value of 18.8 nM.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(phenylmethyl)-adenosine, 5?-[hydrogen P-(phosphonomethyl)phosphonate]
  • Correlated keywords
    • PSB12379 CD-73 NTPDase1 NTPDase2 NTPDase3 ENPP-1 ENPP2 ENPP3 P2Y-1 12 P2-Y1 Y12
  • Product Overview:
    PSB-12379 is an inhibitor of ecto-5’-nucleotidase (CD73; Kis = 2.21 and 9.03 nM for the recombinant human and rat enzyme, respectively).{50087} It is selective for CD73 over human nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), -2, and -3, ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), -2, and -3 (Kis = >10,000 nM for all), as well as the purinergic P2Y1 and P2Y12 receptors at 10 µM. PSB-12379 inhibits CD73 in isolated human serum with a Ki value of 18.8 nM.

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