Sennoside B

Sennoside B

CAT N°: 28410
Price:

From 54.00 45.90

Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.{53043,43197} It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells when used at a concentration of 100 µM.{43197} Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (9R,9’S)-5,5′-bis(?-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-[9,9′-bianthracene]-2,2′-dicarboxylic acid
  • Correlated keywords
    • 1344-35-0 gastro-protective Coprosma PGE-2
  • Product Overview:
    Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.{53043,43197} It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells when used at a concentration of 100 µM.{43197} Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.

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