Lipoxin A₄-d₅ MaxSpec^® Standard

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 5S,6R,15S-trihydroxyicosa-7E,9E,11Z,13E-tetraenoic-19,19,20,20,20-d5 acid
• Correlated keywords
  • trihydroxy activation deuterated deuterium GC 5(S),6(R)-LXA4-d5 quantitative standard mass Max spec spectrometry lipidomics LC-MS LCMS
• Product Overview:
  Lipoxin A4-d5 (LXA4-d5) is intended for use as an internal standard for the quantification of LXA4 (Item Nos. 90410 | 10007271) by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4; Item Nos. 20110 | 10007240) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} LXA4-d5 MaxSpec® standard is a quantitative grade standard of LXA4-d5 (Item No. 10007737) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA4-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.