(±)-Synephrine (hydro<wbr/>chloride)

(±)-Synephrine (hydrochloride)

CAT N°: 28398
Price:

From €85.00 €72.25

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to ?1A-, ?2A-, and ?2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of ?1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing ?2A- or ?2C-AR. It also acts as an antagonist of ?1A-, ?2A-, and ?2C-ARs, inhibiting L-phenylephrine-induced activation of ?1A-AR in HEK293 cells and activation of ?2A- and ?2C-ARs induced by the ?2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (±)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-hydroxy-?-[(methylamino)methyl]-benzenemethanol, monohydrochloride
  • Correlated keywords
    • 582-84-3 860222-98-6 Sympatol Oxedrine p-synephrine ?-1A 2A 2C ?1AARs HEK-293 ?2AARs ?2CARs Glut-4 ?2AR
  • Product Overview:
    (±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to ?1A-, ?2A-, and ?2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of ?1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing ?2A- or ?2C-AR. It also acts as an antagonist of ?1A-, ?2A-, and ?2C-ARs, inhibiting L-phenylephrine-induced activation of ?1A-AR in HEK293 cells and activation of ?2A- and ?2C-ARs induced by the ?2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (±)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}

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