Adrenomedullin (13-52) (human) (trifluoroacetate salt)

Adrenomedullin (13-52) (human) (trifluoroacetate salt)

CAT N°: 24891
Price:

385.00 327.25

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) (Item No. 24889).{40902} It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II (Item No. 17150) and endothelin-1 (Item No. 24127) from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Item No. 16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure.{39626} It also potentiates inflammatory edema and neutrophil accumulation in rats.{40903}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-?-aspartyl-L-lysyl-L-?-aspartyl-L-lysyl-L-?-aspartyl-L-asparaginyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-L-prolyl-L-glutaminylglycyl-L-tyrosinamide, cyclic (4?9)-disulfide, trifluoroacetate salt
  • Correlated keywords
    • 154765-05-6 NH2 NH-2 vascular vasodialator U46619
  • Product Overview:
    Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) (Item No. 24889).{40902} It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II (Item No. 17150) and endothelin-1 (Item No. 24127) from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Item No. 16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure.{39626} It also potentiates inflammatory edema and neutrophil accumulation in rats.{40903}

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