Globotetraosylceramide (porcine RBC)

Globotetraosylceramide (porcine RBC)

CAT N°: 24881
Price:

872.00 741.20

Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes.{43016} They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19.{43017,43018,43019} Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways.{43020} Levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyper- and hypo-pigmented skin.{43021} This product contains globotetraosylceramides with primarily C24:0, C22:0, and 2-hydroxy C24:0 fatty acyl chains. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1068]

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-O-[O-2-(acetylamino)-2-deoxy-?-D-galactopyranosyl-(1?3)-O-?-D-galactopyranosyl-(1?4)-O-?-D-galactopyranosyl-(1?4)-?-D-glucopyranosyl]-ceramide
  • Correlated keywords
    • 77107-72-3 77538-27-3 132421-04-6 154101-69-6 Globosidic acid Globoside Gb-4 GL GL4 Ganglioside CQH Globotetrahexosylceramide Cytolipin K B-19 Globo-N-tetraosylceramide Stx-1 2 2e hyperpigmented hypopigmented
  • Product Overview:
    Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes.{43016} They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19.{43017,43018,43019} Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways.{43020} Levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyper- and hypo-pigmented skin.{43021} This product contains globotetraosylceramides with primarily C24:0, C22:0, and 2-hydroxy C24:0 fatty acyl chains. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1068]

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