(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is...
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€55.00 €46.75
€55.00 €46.75
Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 ?M) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine ? synthase (CBS) and cystathionine ? lyase (CSE; IC50s = 8.5 and 1.1 ?M, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 250 mg, 500 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 2921-14-4 |
| Molecular formula | C2H5NO3 • 1/2HCl |
| Smiles | OC(CON)=O.OC(CON)=O.Cl |
| Molecular weight | 109,3 |
| Custom code | 2922.29 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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