19,20-Epoxy<wbr/>cytochalasin D

19,20-Epoxycytochalasin D

CAT N°: 28050
Price:

From 313.00 266.05

19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M.{46279} It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.{46279,42800}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1S,3S,3aR,4E,7S,9R,9aR,10aS,11S,11aR,14S,14aR)-11-(acetyloxy)-3,3a,6,7,9,9a,10a,11,14,14a-decahydro-3,9-dihydroxy-1,7,9-trimethyl-2-methylene-14-(phenylmethyl)-1H-oxireno[9,10]cycloundec[1,2-d]isoindole-8,12(2H,13H)-dione
  • Correlated keywords
    • Epoxy-cytochalasin UM-10M UM10-M Plasmodium BT549 LLCPK11 P-388 SKMEL SKOV-3 PK 11
  • Product Overview:
    19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M.{46279} It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.{46279,42800}

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