Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-?-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-?-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-?-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonyl-L-lysyl-L-arginyl-L-asparaginyl-L-arginyl-L-asparaginyl-L-asparaginyl-L-isoleucyl-L-alanine, trifluoroacetate salt
• Correlated keywords
  • 159002-68-3 OXM GLP1R GLP2R
• Product Overview:
  Oxyntomodulin is a peptide hormone involved in regulation of food intake, energy expenditure, and glucose metabolism.{38941} It is produced in gut endocrine L-cells via post-translational processing of preproglucagon by prohormone convertase 1/3 following nutrient uptake. Oxyntomodulin is an agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR; IC50s = 4.3 and 355 nM for rat GCGR and GLP-1R, respectively).{38942} It is selective for GCGR and GLP-1R over GLP-2R and glucose-dependent insulinotrophic peptide receptor (GIPR), as it stimulates cAMP formation in BHK cells expressing rat GCGR and GLP-1R when used at concentrations of 10 or 100 nM, but has no effect on cells expressing rat GLP-2R or GIPR at either concentration.{38944} Oxyntomodulin also stimulates cAMP formation in CHO cells expressing mouse GLP-1R and GCGR (EC50s = 2.5 and 6.2 nM, respectively).{38943} In vivo, oxyntomodulin reduces refeeding in 24-hour fasted rats when injected intracerebroventricularly or into the paraventricular nucleus (PVN) of the hypothalamus at doses of 3 and 1 nmol, respectively.{38945} Oxyntomodulin (50 nmol/kg twice per day for 7 days) reduces cumulative daily food intake and rate of body weight gain in rats.{38946}