TAF 10 Peptide
TAF 10 Peptide
TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...
€191.00
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From €102.00 €86.70
From €102.00 €86.70
IMR-1 is an inhibitor of mastermind-like 1 (Maml1) recruitment to chromatin.{35889} It binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1, but not Notch1, to chromatin. It inhibits colony formation in the Notch-dependent cell lines SUM149, SUM159, and HT-1080, but not the Notch-independent cell lines T47D, MCF-7, and H23 when used at concentrations of 15 and 45 µM. IMR-1 (15 mg/kg) decreases the expression of the Notch target genes HES1, HEYL, and NOTCH3 and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 310456-65-6 |
| Molecular formula | C15H15NO5S2 |
| Smiles | COC1=C(OCC(OCC)=O)C=CC(/C=C2C(NC(S2)=S)=O)=C1, COC1=C(OCC(OCC)=O)C=CC(/C=C2C(NC(S2)=S)=O)=C1, COC1=C(OCC(OCC)=O)C=CC(/C=C2C(NC(S2)=S)=O)=C1 |
| Molecular weight | 353,4 |
| Custom code | 2930.90 |
| Formulation | A crystalline solid |
| Purity | ≥95% (mixture of isomers) |
| UNSPSC code | 12352100 |
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TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...
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