NGP-555

NGP-555

CAT N°: 27918
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From 176.00 149.60

NGP-555 is a modulator of ?-secretase that inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-? (A?; IC50s = 531 and 131 nM for A?40 and A?42, respectively, in HeLa cell membranes).{48964} It is selective for AICD cleavage to A? over E-cadherin and Notch cleavage to their signaling effectors, E-cadherin ?-C-terminal fragment and NICD, respectively, processes also mediated by ?-secretase, when used at a concentration of 30 µM. Dietary administration of NGP-555 (~50 mg/kg per day) reduces cortical and hippocampal plaque area in the Tg2576 transgenic mouse model of Alzheimer’s disease.{48964} NGP-555 (25 mg/kg per day, p.o.) decreases plasma and brain A?40 and A?42 levels, as well as increases spontaneous alternations in the Y-maze, indicating prevention of memory deficits, in Tg2576 mice.{35879}

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