Urocortin III (mouse) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-?-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-isoleucyl-L-methionyl-L-asparaginyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-isoleucyl-L-?-aspartyl-L-lysyl-L-alanyl-L-lysyl-L-asparaginyl-L-leucyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-glutaminyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide, 2,2,2-trifluoroacetate
• Correlated keywords
  • neuro-peptide CRF-2? 2? Spea CRF-1 mouse Stresscopin central nervous system 357952-10-4
• Product Overview:
  Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF (Item No. 24407), urocortin (Item No. 24745), urocortin II (Item No. 24746), frog sauvagine, and piscine urotensin I.{39576} Mouse urocortin III shares 90, 40, 37, and 18% identity to human urocortin III (Item No. 24748), mouse urocortin II (Item No. 24747), human urocortin (Item No. 24744), and mouse urocortin, respectively. It is expressed in the hypothalamus, brainstem, lateral septum (LS)/bed nucleus of stria terminalis (BnST) in the CNS and the small intestine, pancreatic ?-cells, and skin in the periphery in mice. Urocortin III selectively binds to type 2 CRF receptors (Kis = 5, 1.8, and >100 nM for rat CRF2?, rat CRF2?, and human CRF1, respectively). It stimulates cAMP production in CHO cells expressing rat CRF2? and mouse CRF2? (EC50s = 0.073 and 0.08 nM, respectively) as well as in cultured anterior pituitary cells expressing endogenous CRF2?. In vivo, urocortin III (2 ?g, i.p.) accelerates metamorphosis of S. hammondii tadpoles.{39577} Urocortin III (20 ?g, i.c.v.) increases exploration in the open field test and decreases latency to enter the lit compartment in the dark-light emergence test in mice, indicating anxiolytic-like activity, and mRNA expression is increased in mouse brain in response to restraint.{39578} It is co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro and in vivo in wild-type mice, however, it is depleted from ?-cells in mouse and macaque models of type 2 diabetes, suggesting a role in glycemic control.{39579}