β-Defensin-4 (human) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-?-glutamyl-L-leucyl-L-?-aspartyl-L-arginyl-L-isoleucyl-L-cysteinylglycyl-L-tyrosylglycyl-L-threonyl-L-alanyl-L-arginyl-L-cysteinyl-L-arginyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-seryl-L-glutaminyl-L-?-glutamyl-L-tyrosyl-L-arginyl-L-isoleucylglycyl-L-arginyl-L-cysteinyl-L-prolyl-L-asparaginyl-L-threonyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-cysteinyl-L-leucyl-L-arginyl-L-lysine, cyclic (6?33),(13?27),(17?34)-tris(disulfide), trifluoroacetate salt
• Correlated keywords
  • BD4 anti-microbial IL6 IL10 CXCL-10 CCL-2 MIP3? IL31 Escherichia Pseudomonas Staphylococcus Candida
• Product Overview:
  ?-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.{41472} It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.{38795} ?-Defensin-4 (30 ?g/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3?, and RANTES by keratinocytes.{38796} It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 ?g/ml, respectively. ?-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 ?g/ml and by rat mast cells in vivo following a 500 ng intradermal dose.{38797} It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 ?M, respectively, of S. carnosus (MIC = 4.5 ?g/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 ?M.{38795,38798}