ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoro<wbr/>acetate salt)

ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

CAT N°: 27105
Price:

From 92.00 78.20

Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.{49033,45140} The amino acid sequence of ACTH (1-10) is common to ACTH and ?-melanocyte stimulating hormone.{45139} ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).{45139,49034} It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 ?g, respectively.{49033,49035} Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.{49036}

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