From €231.00 €196.35
Noscapine-13C-d3 is intended for use as an internal standard for the quantification of noscapine (Item No. 17255) by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.{28232,28233,49588} It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM.{28233} Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.{49588}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 1217680-57-3 |
| Molecular formula | C21[13C]H20D3NO7 |
| Smiles | COC1=C2C(CCN([13C]([2H])([2H])[2H])[C@@]2([H])[C@]3([H])C(C=CC(OC)=C4OC)=C4C(O3)=O)=CC5=C1OCO5 |
| Molecular weight | 417,4 |
| Custom code | 3822.19 |
| Formulation | A solid |
| Purity | ≥99% deuterated forms (d1-d3) |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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