Kavain

Kavain

CAT N°: 26524
Price:

From 48.00 40.80

Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities.{46119,46120,46121,46122} It is a positive allosteric modulator of ?4?2? subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively, in Xenopus oocytes expressing human receptors.{46119} Kavain reduces growth of WPMY-1 prostate cancer cells (IC50 = 5.2 µg/ml).{46120} It reduces LPS-induced TNF-? production in primary murine macrophages in a concentration-dependent manner.{46121} In vivo, kavain (1 mg/animal) reduces hind paw swelling and TNF-? production in wild-type, but not Erk-/-, mice in a mouse model of collagen-induced arthritis. Kavain also reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg).{46122}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (6R)-5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one
  • Correlated keywords
    • 21282-41-7 3155-48-4 Gonosan NSC112162 Piper ?4?-2? ?-4?2? GABA WPMY1 TNF? WT Lipopolysaccharide
  • Product Overview:
    Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities.{46119,46120,46121,46122} It is a positive allosteric modulator of ?4?2? subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively, in Xenopus oocytes expressing human receptors.{46119} Kavain reduces growth of WPMY-1 prostate cancer cells (IC50 = 5.2 µg/ml).{46120} It reduces LPS-induced TNF-? production in primary murine macrophages in a concentration-dependent manner.{46121} In vivo, kavain (1 mg/animal) reduces hind paw swelling and TNF-? production in wild-type, but not Erk-/-, mice in a mouse model of collagen-induced arthritis. Kavain also reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg).{46122}

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