Funalenone

Funalenone

CAT N°: 23491
Price:

320.00 272.00

Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 ?M) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 ?M) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 ?M).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 ?M) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 ?M.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 ?M in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 ?g/mL.{41697}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one
  • Correlated keywords
    • BMS 304245 BMS304245 Aspergillus HIV1 HPBM MMP1 MMP2 MMP9 Staphylococcus
  • Product Overview:
    Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 ?M) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 ?M) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 ?M).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 ?M) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 ?M.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 ?M in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 ?g/mL.{41697}

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