Doravirine

Doravirine

CAT N°: 26405
Price:

From 122.00 103.70

Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11 nM).{48085} It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-benzonitrile
  • Correlated keywords
    • nonnucleoside K-103N Y-181C HIV1 MK1439 WT K103-N Y181-C 103 181
  • Product Overview:
    Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11 nM).{48085} It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.

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