Gramicidin A

Gramicidin A

CAT N°: 26384
Price:

From 48.00 40.80

Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis.{47164} Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 ? (HIF-1?) in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model when administered at a dose of 0.22 mg/kg three times per week.{47165} Gramicidin A has commonly been used to study channel structure and function.{47164}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (R)-2-((2S,5R,8S,11R,14S,17R,20S,26S)-2-((1H-indol-3-yl)methyl)-17-isobutyl-5,8,11,26-tetraisopropyl-14,20-dimethyl-4,7,10,13,16,19,22,27,28-nonaoxo-3,6,9,12,15,18,21,24,25-nonaazaoctacosanamido)-N-((5S,8R,11S,14R,17S)-5,11-bis((1H-indol-3-yl)methyl)-1-hydroxy-18-(1H-indol-3-yl)-8,14-diisobutyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-17-yl)-4-methylpentanamide
  • Correlated keywords
    • 9062-59-3 4419-81-2 Brevibacillus HIF1? HEK 293 WI38 HSV1 HSV2 anti-biotic
  • Product Overview:
    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis.{47164} Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 ? (HIF-1?) in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model when administered at a dose of 0.22 mg/kg three times per week.{47165} Gramicidin A has commonly been used to study channel structure and function.{47164}

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