24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Met-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of ?- and µ-opioid receptors (Kis = 0.65 and 1.7 nM, respectively).{42332,25533} It is selective for ?- and µ- over ?-opioid receptors (Ki = >1,000 nM).{25533} Met-Enkephalin is a cleavage product of proenkephalin, which is found primarily in the adrenal medulla and the CNS.{42333} Met-Enkephalin is found in the brain, primarily in the globus pallidus, nucleus accumbens, and substantia nigra, the brainstem, and the spinal cord as well as in the peripheral nervous system.{42333,42334} Met-Enkephalin has antinociceptive effects in mouse models of acute pain, including tail pressure, hot plate tail-flick, and acetic acid-induced writhing tests (ED50s = 170, 140, and 88 nmol/animal, respectively).{42335} Levels of Met-enkephalin are increased at the site of inflammation in a complete Freund’s adjuvant mouse model of chronic inflammatory pain.{42336}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 5 mg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C27H35N5O7S • XCF3COOH |
| Smiles | OC1=CC=C(C[C@H](N)C(NCC(NCC(N[C@H](C(N[C@H](C(O)=O)CCSC)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1.FC(F)(C(O)=O)F |
| Molecular weight | 573,7 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom code | 2924.19 |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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