€131.00 €111.35
Endomorphin 1 is an endogenous neuropeptide and ?-opioid receptor agonist (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties.{43252,43253} It is found in the brain and, to a lesser extent, in the spinal cord.{43255} It is selective for ?- over ?- and ?-opioid receptors (Ki = 1,506 and 5,428 nM, respectively).{43252} Endomorphin 1 also binds to mouse brain membranes and rat recombinant ?-opioid receptors expressed in CHO cells (Kis = 0.94 and 0.66 nM, respectively).{43253} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing rat recombinant ?-opioid receptors and in SH-SY5Y human neuroblastoma cells (IC50s = 9.33 and 19.1 nM, respectively).{43254} In mice, endomorphin 1 increases analgesia in a radiant heat tail-flick assay following intracerebroventricular or intrathecal administration (ED50s = 4.75 and 0.726 ?g, respectively) and induces conditioned place preference when administered intracerebroventricularly at a dose of 10 ?g.{43253,43256} Endomorphin 1 (12 ?g, i.c.v.) also decreases gastrointestinal transit time in mice.{43253}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 5 mg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C34H38N6O5 • XCF3COOH |
| Smiles | O=C([C@H]1N(C([C@@H](N)CC2=CC=C(O)C=C2)=O)CCC1)N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)CC4=CNC5=C4C=CC=C5.FC(F)(C(O)=O)F |
| Molecular weight | 610,7 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom code | 2924.19 |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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GST-tag Polyclonal Antibody (FITC) is a probe for the immunochemical detection of GST tags on recombinant proteins. Recombinant proteins are...
The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype...
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that...
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Protein phosphorylation is an important post-translational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein...
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