O-304

O-304

CAT N°: 26186
Price:

From 88.00 74.80

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).{48264} It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O-304 suppresses dephosphorylation of AMPK?, AMPK?, and AMPK? trimers at threonine 172 (T172) mediated by protein phosphatase 2C (PP2C) without inhibiting PP2C activity in Wi-38 lung fibroblasts. In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-benzamide
  • Correlated keywords
    • O304 panactivator ? ? ? T PP 2 C Wi38
  • Product Overview:
    O-304 is a pan-activator of AMP-activated protein kinase (AMPK).{48264} It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O-304 suppresses dephosphorylation of AMPK?, AMPK?, and AMPK? trimers at threonine 172 (T172) mediated by protein phosphatase 2C (PP2C) without inhibiting PP2C activity in Wi-38 lung fibroblasts. In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

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