GSK180736A

GSK180736A

CAT N°: 26182
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GSK180736A is an inhibitor of Rho-associated kinase 1 (ROCK1; IC50 = 14 nM) and G protein-coupled receptor kinase 2 (GRK2; IC50 = 0.77 µM).{26327,42595} It is selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all) and selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively).{26327,42595} GSK180736A increases maximum contractility in isolated mouse cardiomyocytes when used at a concentration of 1 µM.{42595}

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