<em>p</em>-chloro Phenylalanine

p-chloro Phenylalanine

CAT N°: 26168
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p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM).{47198} It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administered at a dose of 300 mg/kg. p-chloro Phenylalanine has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system and its involvement in depressive-like behavior, reward learning, Parkinson’s disease, and pain.{47199,47200,47201,47202}

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