Asciminib

Asciminib

CAT N°: 26126
Price:

From 92.00 78.20

Asciminib is an allosteric inhibitor of Abl1 (IC50 = 0.45 nM).{43921} It is selective for Abl1 over a panel of more than 60 additional kinases (IC50s = >10 ?M), as well as ion channels, nuclear receptors, G protein-coupled receptors (GPCRs), and transporters. Asciminib inhibits the proliferation of Luc-Ba/F3 cells transformed with wild-type Bcr-Abl1 or the drug-resistant mutant Bcr-Abl1T315I (GI50s = 1 and 25 nM, respectively), as well as other drug-resistant mutants.{43922} It reduces tumor growth in a KCL-22 chronic myelogenous leukemia (CML) mouse xenograft model when administered at a dose of 3 mg/kg twice per day and induces tumor regression at doses of greater than or equal to 7.5 mg/kg twice per day.

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